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. 2021 Jun 30;21:303. doi: 10.1186/s12893-021-01298-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Differentially expressed genes (DEGs) in the inflammatory phase, and Gene Ontology (GO) and KEGG pathway analysis of DEGs. A Volcano plot representing DEGs on the third-postoperative-day (3rd POD) compared with intact skin (control). B Volcano plot representing DEGs on the seventh-postoperative-day (7th POD) compared with control. C Venn diagram displaying overlapping genes that were significantly differentially expressed on the 3rd and 7th POD, compared with the control. D Ten most significantly enriched KEGG pathways and numbers of genes involved; E Ten most significantly enriched GO terms for biological processes and numbers of genes involved; F Ten most significantly enriched GO terms for cellular components and numbers of genes involved gene numbers; G Ten most significantly enriched GO terms for molecular function of DEGs and numbers of genes involved, in the significantly differentially expressed overlapping genes on the 3rd and 7th POD compared with the control. P < 0.05 defined as significantly enriched