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. 2021 Jun 30;21:303. doi: 10.1186/s12893-021-01298-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Differentially expressed genes (DEGs) in the remodeling phase, and Gene Ontology (GO) and KEGG pathway analysis of DEGs. A Volcano plot representing DEGs on the fourteenth-postoperative-day (14th POD) compared with intact skin (control). B Volcano plot representing DEGs on the twenty first-postoperative-day (21st POD) compared with the control. C Venn diagram displaying significantly differentially expressed overlapping genes on the 14th and 21st POD compared with the control. D The most significantly enriched KEGG pathways and numbers of genes involved; E Ten most significantly enriched GO terms for biological processes and numbers of genes involved; F The most significantly enriched GO terms for cellular components and numbers of genes involved; G The most significantly enriched GO terms for molecular function of DEGs and numbers of genes involved in the overlapping genes that were significantly differentially expressed on the 14th and 21st POD compared with control. P < 0.01 defined as significantly enriched