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. 2021 Jun 30;21:303. doi: 10.1186/s12893-021-01298-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Hub clusters of DEGs in the remodeling phase analyzed by protein–protein interactions (PPI) and hub genes related to KEGG pathway enrichment. A PPI interaction network. Green nodes represent downregulated genes; red nodes represent upregulated genes. B PPI molecular complex detection method (MCODE) component. Highest scoring module identified from the PPI network using the MCODE algorithm with a score of 8.889 (cluster 1), with five key genes involved. C Key genes in the cluster were annotated in the context of the KEGG database and the relationships between these annotated terms were calculated and grouped using ClueGO to create an annotation module network. Genes with connections to more than two terms were defined as hub genes. D The top 10 hub genes in the PPI were screened by Cytoscape plugin cytoHubba based on their connectivity degree