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The effect of OEA or PEA on poly I:C induced (a) hyperthermia and increases in inflammatory gene expression of (b) IP-10, (c) IRF7, (d) TNF-α, (e) IL-1β, (f) IL-10, (g) iNOS, (h) COX2, (i) MPGES, (j) SOCS1 and (k) SOCS3 in the hypothalamus, 4 h post poly I:C administration. Data expressed as mean ± SEM (n = 6–8 per group). ***p < 0.001; **p < 0.01; * p < 0.05 vs vehicle-saline-treated counterparts. ++p < 0.01; +p < 0.05 vs vehicle-poly I:C-treated counterparts.
