Table 1:

List of assays used for machine learning models, available in ToxCast/Tox21; equivalent to those listed in Table 1 of Kleinstreuer et al, 2017 ¹¹.

Assay Abbreviation	Assay ToxCast Name	Brief Description
A1	NVS_NR_hAR	Cell-free radioligand binding assay with human AR
A2	NVS_NR_cAR	Cell-free radioligand binding assay with chimpanzee AR
A3	NVS_NR_rAR	Cell-free b radioligand binding assay with rat AR
A4	OT_AR_ARSRC1_0480	Recruitment assay of coregulator c-Src tyrosine kinase at 8 h
A5	OT_AR_ARSRC1_0960	Recruitment assay of coregulator c-Src tyrosine kinase at 16 h
A6	ATG_AR_TRANS_up	Reporter gene assay measuring mRNA induction after 24 h
A7	OT_AR_ARELUC_AG_1440	Reporter gene assay measuring luciferase induction
A8	TOX21_AR_BLA_Agonist_ratio	Reporter gene assay measuring ratio of cleaved to uncleaved substrate
A9	TOX21_AR_LUC_MDAKB2_Agonist	Reporter gene assay measuring luciferase induction
A10	TOX21_AR_BLA_Antagonist_ratio	Reporter gene assay measuring ratio of cleaved to uncleaved substrate
A11	TOX21_AR_LUC_MDAKB2_Antagonist	Reporter gene assay measuring luciferase induction