Table 2:
Tesamorelin Responders (N=193) | Placebo (N=148) | P value | |
---|---|---|---|
Baseline* | |||
VAT density | −91.2 (8.8) | −91.4 (8.9) | 0.80 |
SAT density | −94.1 (10.7) | −95.3 (10.9) | 0.29 |
26-week change* | |||
VAT density | 6.2 (8.7) | 0.3 (4.2) | <0.001 |
SAT density | 4.0 (8.7) | 0.3 (4.8) | <0.001 |
Difference in 26-week change between Tesamorelin vs Placebo | |||
Unadjusted 26-week change⌘ | Estimated Slope | 95%CI | p-value |
VAT density (95% CI) | 5.9 | (4.5, 7.3) | <0.001 |
SAT density (95% CI) | 3.7 | (2.3, 5.2) | <0.001 |
Adjusted 26-week change**⌘ | |||
VAT density (95% CI) | 2.3 | (0.9, 3.7) | 0.001 |
SAT density (95% CI) | 3.5 | (2.3, 4.7) | <0.001 |
mean (standard deviation)
adjusted for baseline AT density, baseline AT area and change in AT area
HU effect size estimate and 95% confidence interval
AT=adipose tissue, VAT=visceral adipose tissue, SAT=subcutaneous adipose tissue, HU=Hounsfield Units