TABLE 4.
Association of histological subtypes of lung cancer with a 1-SD increment in dietary indices in the WHI OS1
| Tumor histology | n | HEI-20152 | AHEI-20102 | aMED2 | DASH2 |
|---|---|---|---|---|---|
| Lung cancer incidence (n = 1483) | |||||
| Small cell lung cancer | 121 | 0.99 (0.86, 1.14) | 0.92 (0.80, 1.06) | 0.96 (0.84, 1.11) | 0.90 (0.78, 1.04) |
| Non–small cell lung cancer | 1362 | 0.98 (0.94, 1.02) | 0.99 (0.95, 1.03) | 0.98 (0.94, 1.02) | 1.00 (0.96, 1.04) |
| Adenocarcinoma | 552 | 0.98 (0.92, 1.05) | 1.05 (0.98, 1.12) | 1.01 (0.95, 1.08) | 1.05 (0.98, 1.12) |
| Squamous cell | 190 | 0.85 (0.76, 0.96)3 | 0.87 (0.78, 0.98)3 | 0.90 (0.81, 0.99)3 | 0.87 (0.77, 0.98)3 |
| Large cell/neuroendocrine | 54 | 1.21 (0.98, 1.49) | 1.03 (0.84, 1.27) | 1.15 (0.94, 1.42) | 0.94 (0.77, 1.15) |
| Carcinoma NOS | 181 | 0.97 (0.86, 1.09) | 0.94 (0.84, 1.05) | 0.93 (0.83, 1.04) | 0.94 (0.84, 1.06) |
| Other | 385 | 1.00 (0.93, 1.08) | 0.99 (0.91, 1.07) | 0.96 (0.89, 1.03) | 1.02 (0.95, 1.10) |
| Lung cancer mortality (n = 844) | |||||
| Small cell lung cancer | 101 | 1.03 (0.89, 1.20) | 0.93 (0.80, 1.09) | 0.95 (0.82, 1.11) | 0.93 (0.80, 1.08) |
| Non–small cell lung cancer | 743 | 0.99 (0.93, 1.04) | 1.00 (0.94, 1.05) | 1.01 (0.95, 1.06) | 1.00 (0.95, 1.06) |
| Adenocarcinoma | 305 | 0.99 (0.90, 1.08) | 1.04 (0.95, 1.14) | 1.03 (0.94, 1.12) | 1.05 (0.96, 1.14) |
| Squamous cell | 111 | 0.87 (0.74, 1.02) | 0.91 (0.78, 1.06) | 0.93 (0.80, 1.08) | 0.89 (0.77, 1.04) |
| Large cell/neuroendocrine | 34 | 1.29 (0.99, 1.68) | 1.05 (0.81, 1.36) | 1.21 (0.93, 1.57) | 0.94 (0.73, 1.21) |
| Carcinoma NOS | 130 | 1.01 (0.88, 1.15) | 0.98 (0.85, 1.12) | 0.97 (0.85,1.11) | 0.98 (0.86, 1.12) |
| Other | 163 | 0.99 (0.88, 1.12) | 0.98 (0.87, 1.10) | 1.00 (0.89, 1.13) | 1.02 (0.91, 1.14) |
Values are number of subjects or aHRs (95% CIs). 1-SD units for the dietary indices were HEI-2015,10.74; AHEI-2010, 11.19; aMED, 1.79; DASH, 4.87. AHEI, Alternate Healthy Eating Index; aHR, adjusted HR; aMED, Alternate Mediterranean Diet; DASH, Dietary Approaches to Stop Hypertension; HEI, Healthy Eating Index; NOS, not otherwise specified; WHI OS, Women's Health Initiative Observational Study.
Adjusted for age (years), active smoking (never smokers, former smoker <10 pack y , former smoker 10–<24.9 pack y, former smoker ≥25 pack y, current smoker <10 pack y, current smoker 10–<24.9 pack y and current smoker ≥25 pack y), y of exposure to secondhand smoke during childhood and as an adult (living and working) race, education, body mass index, physical activity (MET h/wk), and energy intake.
aHR (95% CIs) values are statistcally significant.