Table 1.
Clinical characteristics of the overall study population, and analyses for associations with Aβ deposition
| Total sample (n=257) | Aβ absent (n=174) | Aβ present (n=83) | Association with Aβ | ||
|---|---|---|---|---|---|
| Univariate, P value | Multivariate1, P value, (OR; 95% CI) | ||||
| Mean age (SD) | 52.8 (12.1) | 50.3 (12.4) | 58.0 (9.8) | <0.0001 | <0.0001 (1.07; 1.04,1.11) |
| Male gender, n (%) | 160 (62%) | 116 (67%) | 44 (53%) | 0.0356 | |
| Race/ethnicity, n (%) | 0.8512 | ||||
| Hispanic | 86 (33%) | 60 (34%) | 26 (31%) | ||
| Other | 7 (3%) | 5 (3%) | 2 (2%) | ||
| HIV positive, n (%) | 194 (75%) | 139 (80%) | 55 (66%) | 0.0187 | 0.0274 (0.47; 0.23,0.92) |
| APOE ε4, n (%) | 77 (30%) | 40 (23%) | 37 (45%) | 0.0005 | <0.0001 (3.97; 2.10,7.69) |
| APOE ε2, n (%) | 48 (19%) | 38 (22%) | 10 (12%) | 0.0633 | |
| HCV, n (%) | 120 (47%) | 78 (45%) | 42 (51%) | 0.3859 | |
| HBV, n(%) | 111 (43%) | 79 (45%) | 32 (39%) | 0.3006 | |
| Any viral hepatitis, n (%) | 166 (65%) | 111 (64%) | 55 (66%) | 0.6985 | |
| Any herpes infection, n (%) | 102 (40%) | 70 (40%) | 32 (39%) | 0.7974 | |
| On herpes therapy, n (%) | 65 (25%) | 45 (26%) | 20 (24%) | 0.7608 | |
| Hypertension | 119 (46%) | 73 (42%) | 46 (55%) | 0.0429 | |
| Diabetes mellitus | 68 (26%) | 37 (21%) | 31 (37%) | 0.0063 | |
1
Statistically significant (p<0.05) terms shown.