Table 3.
Histologic patterns of Aβ accumulation in HIV-, HIV+ short duration, and HIV+ long duration participants
| HIV negative (n=63) | HIV duration<15 (n=82) | HIV duration>=15 (n=98) | P-value | |
|---|---|---|---|---|
| Mean Age1,2,3 (SD) | 53.3 (14.9) | 46.6 (9.8) | 56.8 (9.9) | <0.0001 |
| Gray matter Aβ1,2, n (%) | 28 (44%) | 9 (11%) | 42 (43%) | <0.0001 |
| White matter Aβ3 , n (%) | 2 (3.2%) | 4 (4.9%) | 11 (11.2%) | 0.1516 |
| Aβ at pia limitans1,2 (molecular layer), n (%) | 8 (12.7%) | 1 (1.2%) | 16 (16.3%) | 0.0009 |
| Glial Aβ1,2,3, n (%) | 38 (60%) | 20 (24%) | 46 (47%) | <0.0001 |
| Congophilic angiopathy1,2, n (%) | 6 (9.5%) | 1 (1.2%) | 9 (9.2%) | 0.0344 |
| Frontal cortex Aβ1,2, n (%) | 25 (40%) | 8 (10%) | 40 (41%) | <0.0001 |
| Temporal cortex Aβ1,2 n (%) | 15 (24%) | 5 (6.1%) | 27 (28%) | 0.0003 |
Duration of HIV disease data not available for 14 individuals. Analyses by Fisher’s exact test with exception of age, which used simple ANOVA.
1
Pairwise comparison between HIV- and short duration HIV+ significant (p<0.05)
2
Pairwise comparison between long duration HIV+ and short duration HIV+ significant (P<0.05)
3
Pairwise comparison between HIV- and long duration HIV+ at trend level (P<0.10)