Table 5.
Differences of characteristics of BSI burn patients receiving appropriate and inappropriate empirical antimicrobial therapy
| Variable | Empirical antimicrobial therapy | ||
|---|---|---|---|
| Appropriate n = 79 |
Inappropriate n = 57 |
p-value | |
| Male | 59 (74.7) | 41 (71.9) | 0.719 |
| Age (years) (median, IQR) | 47 [34,54] | 46 [38,56] | 0.601 |
| Comorbidities | 19 (24.1) | 15 (26.3) | 0.763 |
| Type of burn | |||
| Flame | 70 (88.6) | 46 (80.7) | 0.199 |
| Chemical | 2 (2.5) | 3 (5.3) | 0.404 |
| Hyperthermia liquid | 5 (6.3) | 7 (12.3) | 0.227 |
| Other | 2 (2.5) | 1 (1.8) | 0.761 |
| %TBSA | |||
| 20–39 | 16 (20.3) | 11 (19.3) | 0.341 |
| 40–59 | 19 (24.1) | 13 (22.8) | |
| 60–79 | 23 (29.1) | 10 (17.5) | |
| ≥ 80 | 21 (26.6) | 23 (40.4) | |
| Accompanying third degree burns | 73 (92.4) | 53 (93.0) | 0.899 |
| Inhalation injury | 51 (64.6) | 29 (50.9) | 0.110 |
| Mechanical ventilation | 48 (60.8) | 34 (59.6) | 0.896 |
| Coinfections before bacteremia | |||
| Skin infection | 65 (82.3) | 37 (64.9) | 0.021 |
| Pneumonia | 38 (48.1) | 19 (33.3) | 0.085 |
| CVC infection | 24 (30.4) | 14 (24.6) | 0.456 |
| UTI | 3 (3.8) | 3 (5.3) | 0.681 |
| AKI | 9 (11.4) | 13 (22.8) | 0.074 |
| Septic shock | 9 (11.4) | 9 (15.8) | 0.455 |
| MODS | 7 (8.9) | 12 (21.1) | 0.043 |
| Hospital length of stay, days (median, IQR) | 51 [34,68] | 47 [30,66] | 0.642 |
| Inappropriate definitive antimicrobial therapy | 3 (3.8) | 13 (22.8) | 0.001 |
| Outcomes | |||
| 30-day mortality | 6 (7.6) | 10 (17.5) | 0.076 |
| 60-day mortality | 11 (13.9) | 14 (24.6) | 0.114 |
BSI bloodstream infection, IQR interquartile range, TBSA total body surface area, CVC central venous catheter, UTI urinary tract infection, AKI acute kidney injury, MODS multiple organ dysfunction syndrome