Table 6.
Univariate and multivariate Cox regression analyses of variables associated with 30-day mortality of BSI in burn patients
| Variable | Crude analysis | Adjusted analysis | ||
|---|---|---|---|---|
| HR (95%CI) | p value | HR (95%CI) | p value | |
| Male | 0.70 (0.20–2.47) | 0.583 | ||
| Age | 1.00 (0.97–1.04) | 0.856 | ||
| Comorbidities | 0.72 (0.21–2.53) | 0.609 | ||
| Type of burn (Flame) | 0.52 (0.17–1.60) | 0.253 | ||
| ≥ 80% TBSA | 0.14 (0.05–0.44) | 0.001 | 0.86 (0.22–3.38) | 0.861 |
| Accompanying third degree burns | 22.7 (0.01,7204.37) | 0.448 | ||
| Inhalation injury | 1.55 (0.54–4.46) | 0.417 | ||
| Mechanical ventilation | 10.77 (1.42–81.54) | 0.021 | 4.14 (0.41–41.53) | 0.228 |
| Coinfections before bacteremia | ||||
| Skin infection | 0.72 (0.25–2.08) | 0.546 | ||
| Pneumonia | 1.40 (0.53–3.72) | 0.503 | ||
| CVC infection | 0.36 (0.08–1.57) | 0.171 | ||
| UTI | 1.43 (0.19–10.84) | 0.728 | ||
| AKI | 42.85 (12.10–151.78) | < 0.001 | 12.26 (2.31–64.98) | 0.003 |
| Septic shock | 36.98 (12.79–106.87) | < 0.001 | 4.36 (1.16–16.34) | 0.031 |
| Inappropriate empirical antimicrobial therapy | 0.42 (0.15–1.16) | 0.093 | 0.56 (0.17–1.89) | 0.351 |
| Inappropriate definitive antimicrobial therapy | 0.25 (0.09–0.72) | 0.010 | 0.52 (0.12–2.19) | 0.371 |
HR hazard ratio, CI confidence interval, TBSA total body surface area, CVC central venous catheter, UTI urinary tract infection, AKI acute kidney injury