Table 1.
Viral clearance/inactivation (LRV) for BG505 DS-SOSIP.664 downstream process unit operations*.
| XMuLV (LRV) | MVM (LRV) | |||
|---|---|---|---|---|
| Experiment 1 | Experiment 2 | Experiment 1 | Experiment 2 | |
| S/D Treatment (60 min) | 2.57 | 2.81 | Not Applicable | |
| Chromatography 2: AEX | 5.17 | 4.97 | 3.13 | 2.97 |
| 20 nm Filtration | > 6.41 | > 6.52 | > 7.60 | > 7.52 |
| Chromatography 3: HIC | 3.76 | 3.63 | 3.83 | 3.91 |
| Total | > 17.92 | > 14.48 | ||
*
Abbreviations include S/D: solvent/detergent, AEX: anion exchange, HIC: hydrophobic interaction chromatography, XMulV: Xenotropic murine leukemia virus, MVM: minute virus of mice, LRV: log reduction value.