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. Author manuscript; available in PMC: 2021 Jun 30.
Published in final edited form as: Neurobiol Dis. 2021 Feb 11;152:105296. doi: 10.1016/j.nbd.2021.105296

Fig. 4.

Fig. 4.

Gabrg2+/K328M KI mice had age-dependent hyperthermic seizures. Mice were placed in a 42 °C incubator for 30 min. The percentage of mice remaining free of myoclonic seizures (A, C, E) or GTCS (B, D, F) during hyperthermia to 42 °C was plotted against duration of hyperthermia. The Mantel-Cox method was used to analyze the difference between WT and KI mice. A. For P15–17 mice, myoclonic seizures were observed in 1 of 27 KI mice and none of 24 WT mice within 30 min of hyperthermia (n = 24 WT and 27 KI, p = 0.34). B. No GTCS was observed for both KI and WT mice. C. For P20 mice, myoclonic seizures were observed in 4 of 9 KI mice and none of 13 WT mice (n = 13 WT and 9 KI, p = 0.008). D. No GTCS was observed for both KI and WT mice. E. For mice older than P30 mice, myoclonic seizures were observed in 19 of 21 KI mice and 1 of 21 WT mice (n = 21 WT and 21 KI, p < 0.0001). F. GTCS observed in 7 of 21 KI mice and none of 21 WT mice (n = 21 WT and 21 KI, p = 0.004).