TABLE 3.
HRs of incident atrial fibrillation according to baseline n–3 PUFA concentrations in Multi-Ethnic Study of Atherosclerosis participants1
| Quartiles of plasma phospholipid FAs2 | |||||
|---|---|---|---|---|---|
| PUFA | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | SD increment3 |
| Phospholipid ALA, % total FA (median = 0.16) | |||||
| n cases/total | 182/1563 | 219/1572 | 215/1538 | 197/1556 | 813/6229 |
| HR (95% CI) | 1 (referent) | 1.19 (0.98, 1.46) | 1.10 (0.90, 1.35) | 1.12 (0.91, 1.38) | 1.00 (0.94, 1.07) |
| Phospholipid EPA, % total FA (median = 0.67) | |||||
| n cases/total | 197/1567 | 187/1545 | 208/1558 | 221/1559 | 813/6229 |
| HR (95% CI) | 1 (referent) | 0.88 (0.72, 1.08) | 0.95 (0.78, 1.16) | 0.93 (0.76, 1.15) | 1.03 (0.96, 1.10) |
| Phospholipid n–3 DPA, % total FA (median = 0.90) | |||||
| n cases/total | 227/1563 | 196/1562 | 180/1548 | 210/1556 | 813/6229 |
| HR (95% CI) | 1 (referent) | 0.83 (0.68, 1.00) | 0.78 (0.64, 0.95)4 | 0.88 (0.72, 1.06) | 0.96 (0.89, 1.03) |
| Phospholipid DHA, % total FA (median = 3.58) | |||||
| n cases/total | 200/1567 | 200/1561 | 219/1547 | 194/1554 | 813/6229 |
| HR (95% CI) | 1 (referent) | 0.81 (0.66, 0.99)4 | 0.89 (0.71, 1.10) | 0.78 (0.62, 0.98)4 | 0.95 (0.87, 1.03) |
| Phospholipid EPA + DHA + n–3 DPA, % total FA (median = 1.77) | |||||
| n cases/total | 208/1568 | 190/1545 | 205/1558 | 210/1558 | 813/6229 |
| HR (95% CI) | 1 (referent) | 0.88 (0.72, 1.07) | 0.90 (0.74, 1.10) | 0.88 (0.72, 1.08) | 0.98 (0.90, 1.06) |
Cox proportional hazard model adjusted for age, race/ethnicity, sex, education, income, site, height, BMI, cigarette smoking, diabetes, blood pressure, antihypertensive medication, physical activity, and alcohol consumption. ALA, α-linolenic acid; DPA, docosapentaenoic acid; FA, fatty acid.
Quartile ranges were as follows: ALA: first, 0.03–0.12; second, 0.12–0.16; third, 0.16–0.20; fourth, 0.20–2.54; EPA: first, 0.09–0.48; second, 0.48–0.67; third, 0.67–0.99; fourth, 0.99–14.46; n–3 DPA: first, 0.04–0.77; second, 0.77–0.90; third, 0.90–1.05; fourth, 1.05–2.42; DHA: first, 0.57–2.71; second, 2.71–3.58; third, 3.58–4.68; fourth, 4.68–10.56; EPA + DHA + n–3 DPA: first, 0.51–1.46; second, 1.46–1.77; third, 1.77–2.21; fourth, 2.21–15.97.
SD increment = 0.08 (phospholipid ALA), 0.79 (phospholipid EPA), 0.23 (phospholipid n–3 DPA), 1.48 (phospholipid DHA), and 0.93 (phospholipid DHA + n–3 DPA + EPA).
0.01 < P < 0.05.