TABLE 4.
HRs of incident atrial fibrillation according to baseline n–6 PUFA concentrations in Multi-Ethnic Study of Atherosclerosis participants1
| Quartiles of plasma phospholipid FAs2 | |||||
|---|---|---|---|---|---|
| PUFA | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | SD increment3 |
| Phospholipid LA, % total FA (median = 20.1) | |||||
| n cases/total | 221/1544 | 188/1545 | 201/1568 | 203/1572 | 813/6229 |
| HR (95% CI) | 1 (referent) | 0.87 (0.71, 1.06) | 0.95 (0.78, 1.16) | 1.04 (0.84, 1.29) | 1.02 (0.94, 1.10) |
| Phospholipid AA, % total FA (median = 11.55) | |||||
| n cases/total | 229/1577 | 238/1562 | 169/1565 | 177/1525 | 813/6229 |
| HR (95% CI) | 1 (referent) | 1.03 (0.86, 1.24) | 0.71 (0.58, 0.87)4 | 0.79 (0.64, 0.98)5 | 0.89 (0.82, 0.96)4 |
| Phospholipid LA + AA, % total FA (median = 32.03) | |||||
| n cases/total | 234/1562 | 214/1557 | 185/1545 | 180/1565 | 813/6229 |
| HR (95% CI) | 1 (referent) | 0.98 (0.81, 1.18) | 0.88 (0.72, 1.07) | 0.89 (0.72, 1.09) | 0.93 (0.87, 1.00) |
Cox proportional hazard model adjusted for age, race/ethnicity, sex, education, income, site, height, BMI, cigarette smoking, diabetes, blood pressure, antihypertensive medication, physical activity, and alcohol consumption. AA, arachidonic acid; FA, fatty acid; LA, linoleic acid.
Quartile ranges: LA: first, 5.66–18.00; second, 18.00–20.10; third, 20.10–22.33; fourth, 22.33–36.13; AA: first, 1.71–9.84; second, 9.84–11.53; third, 11.53–13.32; fourth, 13.32–22.17; LA + AA: first, 8.23–29.95; second, 29.95–32.03; third, 32.03–34.00; fourth, 34.00–47.30.
SD increment = 3.30 (phospholipid LA), 2.54 (phospholipid AA), and 3.27 (phospholipid AA + LA).
0.001 < P < 0.01.
0.01 < P < 0.05.