FIGURE 1.

Serotonergic pathways involved in regulation of food intake. Blue ovals indicate brain regions or nuclei. Orange ovals indicate anorexigenic neuronal populations. Green ovals indicate orexigenic neuronal populations. Green lines indicate excitatory projections. Orange lines indicate inhibitory projections. Most ascending serotonergic projects arise from the dorsal and medial raphe nuclei. Note that connections to the mesolimbic (hedonic) and other brain regions have been simplified for clarity. AgRP, agouti‐related protein; ARC, arcuate nucleus; BDNF, brain‐derived neurotrophic factor; CCK, cholecystokinin; CeA, central nucleus of the amygdala; CGRP, calcitonin gene‐related peptide; DMN, dorsomedial nucleus; GLP1, glucagon‐like peptide 1; LHA, lateral hypothalamic area; MCH, melanin‐concentrating hormone; NAc, nucleus accumbens; NPY, neuropeptide Y; NTS, nucleus tractus solitarius; PBN, parabrachial nucleus; PFC, prefrontal cortex; POMC, proopiomelanocortin; PVN, paraventricular nucleus; PVT, paraventricular thalamic nucleus; VMN, ventral medial nucleus; VTA, ventral tegmental area