TABLE 1.

Modulation of serotonin receptor subtypes affects food intake and/or body weight

Receptor subtype	Effect of
	Receptor knockout	Agonist	Antagonist
5‐HT1A	Inconsistent/= FI and BW 24 , 25 , 26	↑ FI 27 , 28 , 29 ↓ FI (NAc) 30	↓ palatable FI 27
5‐HT1B	Slightly ↑ FI and BW 25 , 31	↓ FI 32 , 33 , 34 ↓ FI (AgRP neurons/VMN/PBN) 35 , 36 , 37
5‐HT2A	= FI and BW 38	↓ FI 39 ↑ FI (CeA; via direct 5‐HT2A + neuron activation) 40
5‐HT2C	↑ FI and BW 41 , 42	↓ FI 18 , 43 ↓ FI (POMC neurons/VMN) 36 , 44 , 45 ↓ motivational FI (NAc/VTA; via direct 5‐HT2C + neuron activation) 30 , 46	↑ FI 47
5‐HT3A	= FI and BW 48	= FI 48 ↓ FI [NTS (AgRP‐ablated)] ↓ FI (VTA) 49 ↑ FI (NAc) 49	= FI 48 ↓ CCK‐mediated inhibition of gastric emptying 50 ↑ FI (rostral NTS)
5‐HT4	= basal FI 51 ↓ stress‐induced hypophagia 51	↓ FI (NAc) 52	↑ FI in the fed state (NAc) 53
5‐HT6	↓ FI and BW on high‐fat diet 54	↓ FI and BW 55 ↑ (NAc) 30	↓ FI and BW 56
5‐HT7	= BW 57	↓ (NAc at higher dose) 30 ↑ (NAc at lower dose) 30

Note: Presented are the effects of systemic receptor agonism/antagonism, unless a region is specified.

Abbreviations: 5‐HT, 5‐hydroxytryptamine; AgRP, agouti‐related peptide; BW, body weight; CCK, cholecystokinin; CeA, central nucleus of the amygdala; FI, food intake; NAc, nucleus accumbens; NTS, nucleus tractus solitaries; NPY, neuropeptide Y; PBN, parabrachial nucleus; POMC, proopiomelanocortin; VMN, ventral medial nucleus; VTA, ventral tegmental area.