TABLE 1.

Characteristics of included studies

Data	Frequency N = 68	Percentage (IC 95%)
Impact Factor (IF) of the Journal
< 1.0	08	11.8 (6.1–21.5)
≥ 1.0 e < 3.0	50	73.5 (61.9–82.5)
≥ 3.0	07	10.3 (5.1–19.8)
Whithout IF	03	4.4 (1.5–12.2)
The jornal endorse the CONSORT	40	58.8 (47.0–69.7)
Year of publication
Before 2010	20	29.4 (19.9–41.1)
After 2010	48	70.6 (58.9. – 80.1)
Continent where the studty made
Asia	27	39.7 (28.9–51.6)
Europe	24	35.3 (25.0–47.2)
North America	11	16.2 (9.3–26.7)
Oceania	03	4.4 (1.5–12.2)
Europe‐Asia	02	2.9 (0.8–10.1)
Not informed	01	1.5 (0.3–7.9)
Sample size
< 100 participants	57	83.8 (73.3–90.7)
≥ 100 participants	11	16.2 (9.3–26.7)
Multicentric study	21	30.9 (21.2–42.6)
Funding Status
Only other funding different of industry	26	38.2 (27.6–50.1)
Only Industry sponsored	11	16.2 (9.3–26.7)
Industry and others	03	4.4 (1.5–12.2)
No funding	04	5.9 (2.3–14.2)
No declared	24	35.3 (25.0–47.9)
Pharmacological intervention	24	35.3 (25.0–47.9)
Intervention category
Topical	23	33.8 (23.7–45.7)
Physical therapy	17	25.0 (16.2–36.4)
Systemic Therapy	16	23.5 (15.0–34.8)
Negative pressure therapy	07	10.3 (5.1–19.8)
Others	05	7.3 (3.2–16.1)