TABLE 4.

Multivariate Cox proportional‐hazards model for all‐cause mortality, minor, and major amputation

		95% CI
Covariates	exp (coef)	Lower	Upper	z	P value
All‐cause mortality a
Age (years)	1.07	1.05	1.08	9.53	<.001
Major amputation	1.80	1.35	2.40	4.03	<.001
PAD	1.37	1.06	1.77	2.43	.015
IHD	10.77	3.28	35.34	3.92	<.001
Previous stroke	1.22	1.01	1.48	2.05	.041
ESRF	1.37	1.12	1.68	3.04	.002
Age*IHD	0.97	0.96	0.99	−2.99	.003
Major amputation b
Age (years)	1.04	1.01	1.07	3.04	.002
IHD	12.27	1.21	124.19	2.12	.033
PAD	27.95	3.98	200.64	3.31	<.001
ESRF	1.92	1.27	2.90	3.11	.002
Age*IHD	0.97	0.94	1.00	−1.85	.064
Minor amputation c
PAD	7.39	5.15	10.61	10.84	<.001
Male	1.35	1.13	1.60	3.34	<.001

Abbreviations: ESRF, end‐stage renal failure; IHD, ischaemic heart disease; PAD, peripheral arterial disease.

^a Likelihood ratio test = 279.3, P = <.001; Wald test = 228.6, P = <.001.

^b Likelihood ratio test = 80.6, P < .001; Wald test = 36.7, P < .001.

^c Likelihood ratio test = 232.9, P = <.001; Wald test = 130.1, P = <.001.