TABLE 1.
24‐h urine solute excretion, urine solute concentration, plasma solute concentration and water balance in control rats and in rats with 5/6 renal mass reduction (5/6 Nx)
| Control (n = 6) | 5/6 Nx (n = 12) | P value | |
|---|---|---|---|
| 24‐h Food Intake and Solute Excretion | |||
| Food Intake (g/kg/d) | 50.1 ± 4.8 | 54.0 ± 7.0 | .243 |
| UNaV (mmol/kg/d) | 3.7 ± 0.4 | 3.6 ± 1.0 | .748 |
| UKV (mmol/kg/d) | 8.8 ± 1.2 | 9.2 ± 1.4 | .584 |
| UUreaV (mmol/kg/d) | 40.9 ± 4.9 | 40.0 ± 11.8 | .867 |
| 24‐h Water Intake, Urine Volume and Water Balance Gap | |||
| Water Intake (mL/kg/d) | 67.6 ± 2.9 | 120.1 ± 20.4 | <.001 |
| Urine Volume (mL/kg/d) | 30.2 ± 3.8 | 60.7 ± 15.1 | <.001 |
| Water Balance Gap (mL/kg/d) | 37.0 ± 3.1 | 60.0 ± 12.6 | <.01 |
| Δ Body Weight (g) | −4.7 ± 2.9 | −7.3 ± 9.5 | .529 |
| 24‐h Urine Solute Concentration and Free Water Clearance | |||
| Urine [Na+] (mmol/L) | 124.7 ± 23.4 | 59.3 ± 12.2 | <.001 |
| Urine [K+] (mmol/L) | 292.7 ± 29.2 | 156.9 ± 25.8 | <.001 |
| Urine [Urea] (mmol/L) | 1372 ± 234 | 677 ± 184 | <.001 |
| Urine Osmolality (mOsm/kg) | 2004 ± 249 | 1009 ± 143 | <.001 |
| Free Water Clearance (mL/kg/d) | −188.4 ± 23.3 | −154.5 ± 30.9 | <.05 |
| Plasma Solute Concentrations and Plasma Osmolality | |||
| Plasma [Na+] (mmol/L) | 138.9 ± 1.8 | 138.8 ± 2.0 | .912 |
| Plasma [K+] (mmol/L) | 6.6 ± 0.5 | 7.3 ± 0.7 | <.05 |
| Plasma [Urea] (mmol/L) | 4.1 ± 0.8 | 9.7 ± 1.6 | <.001 |
| Plasma Osmolality (mOsm/kg) | 282 ± 7 | 289 ± 4 | <.05 |
Data are expressed as average ± SD.