FIGURE 1.

LncRNAs can influence PPARγ's transcription and activity at multiple levels. Specifically, lncRNAs can modulate directly PPARγ by inhibiting DNA methylation. They can also selectively induce a different PPARγ mRNA splicing or sponge‐specific miRNAs which would sequester and lead to degradation of PPARγ's mRNA. They directly bind to the PPARγ protein being able to inhibit its activity through upregulation of the PPARγ repressor complex. Lastly, PPARγ itself can induce the expression of specific lncRNAs. Made in ©BioRender—biorender.com