Table 2.
Hormonal, metabolic, and anthropometric changes at the completion of 12 weeks of treatment
| Parameters | MET (n = 50) | EX (n = 50) | COM (n = 50) | P value | |||
|---|---|---|---|---|---|---|---|
| Before treatment | After treatment | Before treatment | After treatment | Before treatment | After treatment | ||
| Hormonal levels | |||||||
| LH, IU/L | 7.81 (4.46, 12.00) | 6.16 (4.49, 8.09)** | 7.59 (4.59, 9.22) | 6.86 (4.15, 9.13) | 7.49 (5.17, 10.18) | 6.50 (4.03, 7.07)* | .193 |
| FSH, IU/L | 6.32 (5.51, 7.64) | 6.26 (4.67, 7.19) | 5.69 (4.38, 6.54) | 6.08 (4.31, 6.76) | 6.46 (5.30, 7.88) | 6.51 (5.55, 6.94) | .211 |
| DHEAS, ng/ml | 255.07 (189.50, 339.00) | 246.00 (230.00, 302.25) | 225.50 (181.25, 276.50) | 211.00 (160.75, 266.25) | 248.31 (214.40, 324.25) | 234.50 (201.00, 291.25) | .684 |
| T, nmol/L | 2.21 ± 0.97 | 1.86 ± 0.82* | 2.26 (1.91, 2.68) | 2.03 (1.72, 2.45)* | 2.33 (1.84, 2.85) | 1.89 (1.39, 2.69)** | .627 |
| FAI | 10.75 (7.17, 17.00) | 8.50 (3.89, 12.61)** | 10.17 (7.22, 16.09) | 7.74 (4.90, 12.60)** | 12.83 (8.67, 20.66) | 10.44 (6.41, 13.87)** | .873 |
| SHBG, nmol/L | 19.85 (13.23, 29.80) | 23.15 (15.88, 35.28)** | 22.80 (13.48, 32.90) | 27.20 (19.40, 35.50)** | 14.95 (10.28, 27.28) | 24.07 (18.10, 29.70)* | .94 |
| A2, µg/dL | 4.29 (2.84, 5.61) | 3.31 (2.61, 3.37)* | 4.05 (3.19, 4.53) | 3.28 (2.66, 3.71)** | 4.35 (2.61, 5.10) | 2.66 (2.23, 3.76)** | .204 |
| Lipid levels | |||||||
| TG, mmol/L | 1.55 (1.06, 2.55) | 1.38 (1.26, 1.44)* | 1.84 (1.20, 2.20) | 1.26 (0.93, 1.52)** | 1.99 (1.48, 2.39) | 1.19 (1.04, 1.80)** | .505 |
| TC, mmol/L | 4.59 (4.02, 5.14) | 4.66 (4.49, 4.76) | 4.82 (4.28, 5.39) | 4.70 (4.34, 4.94) | 4.71 (4.19, 5.22) | 4.60 (4.31, 5.21) | .714 |
| HDL, mmol/L | 1.17 (1.08, 1.29) | 1.24 (1.18, 1.28) | 1.18 (1.03, 1.35) | 1.19 (1.03, 1.27) | 1.13 (1.04, 1.26) | 1.12 (0.99, 1.24) | .31 |
| LDL, mmol/L | 3.02 (2.55, 3.44) | 2.52 (2.21, 2.59)** | 2.98 (2.40, 3.33) | 2.71 (2.33, 3.03) | 3.36 (2.82, 3.81) | 2.81 (2.51, 3.21)* | <.05 |
| Anthropometric characteristics | |||||||
| Weight, kg | 80.00 (74.70, 86.00) | 76.00 (68.50, 82.00)** | 80.00 (72.88, 92.75) | 74.55 (68.00, 85.25)** | 83.17 ± 12.98 | 76.65 ± 13.18** | .203 |
| BMI, kg/m2 | 29.64 (28.23, 33.14) | 28.19 (25.91, 30.86)** | 30.99 (27.84, 33.34) | 28.46 (25.69, 31.37)** | 31.66 ± 4.67 | 29.17 ± 4.80** | .158 |
Variables with normal distribution in both Before and After treatment are presented as Mean ± SD, otherwise are presented as median (Q1, Q3).
Abbreviations: COM, combination; EX, exenatide; MET, metformin; LH, luteinizing hormone; FSH, follicle stimulating hormone; DHEAS, dehydroepiandrosterone; T, total testosterone; FT, free testosterone; FAI, free androgen index; SHBG, sex hormone binding globulin; A2, androstenedione; TG, triglyceride; TC, total cholesterol, HDL, high density lipoprotein; LDL, low density lipoprotein; BMI, body mass index. * P < 0.05 and ** P < 0.01 compared with baseline (before treatment);