Fig. 1.
Age-dependent β amyloid (Aβ) plaque deposition in the App KI mouse brain. a Immunohistochemistry for Aβ with the 6E10 antibody in coronal sections of brains from App KI mice of 2-, 4-, 8- and 18-months age. b Densitometry of the area covered by 6E10-positive plaques in App KI mouse brain was measured using Image J. Kruskal–Wallis one-way analysis of variance test with Dunn’s post hoc test (*P < 0.05, **P < 0.01, ***P < 0.001) was used for multiple comparisons between ages. App KI = amyloid precursor protein knock-in (AppNL−G−F/NL−G−F). Scale bar = 300 μm