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. 2021 Jun 30;20:65. doi: 10.1186/s12938-021-00904-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Celastrol inhibits the angiogenesis of HG-induced hRECs. A The branching points in hRECs induced with HG and treated with different concentrations of celastrol were observed by tube formation assay. B Inverted micrographs of branching points in hRECs induced with HG and treated with different concentrations of celastrol. C Representative western blots and D quantitative analysis for expression of HIF-1α and VEGF in hRECs induced with HG and treated with different concentrations of celastrol was detected by Western blot analysis. E The mRNA expression of HIF-1α and VEGF in hRECs induced with HG and treated with different concentrations of celastrol was detected by RT-qPCR analysis. F The expression of ICAM-1 in hRECs induced with HG and treated with different concentrations of celastrol was detected by immunofluorescence assay. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. NG group. ^#P < 0.05, ^##P < 0.01 and ^###P < 0.001 vs. HG group. ^∆P < 0.05 vs. HG + 0.5 μM cela group. ^$P < 0.05 and ^$$$P < 0.001 vs. HG + 1.0 μM cela group. Cela: celastrol