Table 1.

Details of identified strongest path(s) by the application using the KEGG background network

Pathway	# found genes	# pathway genes	FDR-corrected p value	List of found pathway genes
BDNF	4	2	$3.54\times {10}^{-3}$	RAC1, TRAF1
EGFR	11	10	$7.99\times {10}^{-10}$	CBL, CBLB, CBLC, ERBB2, HRAS, JAK1, KRAS, MAPK1, MAPK3, SRC
Hedgehog	10	5	$1.20\times {10}^{-8}$	ARBB2, PRKACA, SMO, STK36, SUFU
IL-1	4	3	$1.35\times {10}^{-5}$	MYD88, TAB1, TRAF6
IL-2	5	3	$5.05\times {10}^{-5}$	JAK1, JAK2, JAK3
IL-3	4	3	$2.88\times {10}^{-5}$	JAK1, JAK2, TYK2
IL-6	5	4	$6.37\times {10}^{-7}$	JAK1, JAK2, TYK2, SOCS3
IL-7	5	2	$3.06\times {10}^{-4}$	JAK1, JAK3
TCR	26	15	$5.28\times {10}^{-12}$	CHUK, FYN, IKBKB, IKBKG, MAP3K14, MAP3K7, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK9, MAP3K1, MAPK8
TGFB	31	15	$1.74\times {10}^{-11}$	MAPK1, MAPK3, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, RHOA, RPCK1, ROCK2, SMAD1, AKT1, MAPK8, RAF1, WWTR1, YAP1
TNF-alpha	10	10	$5.28\times {10}^{-12}$	CASPB, IKBKB, MAP3K1, MAPK10, MAPK8, MAPK9, TAB1, TRADD, TRAF2, TRAF6
WNT	48	25	$5.32\times {10}^{-22}$	CREBBP, CSNK2A1, CSNK2A2, CSNK2B, DVL1, DVL2, DVL3, EP300, GSK3B, MAPK10, MAPK8, MAPK9, PLCB1, PLCB2, PLCB3, PLCB4, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, AKT1, MAPK1, MAPK3, SRC