Table 2.

Details of identified strongest path(s) and sub-optimal strongest path(s) by the application using the STRING background network in four separate runs

Pathway	Iteration 1			Iteration 2	Iteration 3	Iteration 4
	#pathway genes/#found genes	FDR-corrected p value	List of found pathway genes	#pathway genes/#found genes	#pathway genes/#found genes	#pathway genes/#found genes
BDNF	3/4	$2.31\times {10}^{-6}$	GRB2, NGF, SHC1	7/12	12/21	14/28
EGFR	6/8	$1.85\times {10}^{-8}$	AKT1, CBL, GRB2, HRAS, JAK2, PIK3CA	9/22	12/49	19/85
Hedgehog	5/5	$2.34\times {10}^{-13}$	DHH, HHIP, SHH, SMO, SUFU	7/17	7/28	7/46
IL-1	4/5	$3.36\times {10}^{-9}$	IKBKB, MAP3K7, TAB2, TRAF6	7/10	7/19	9/38
IL-2	2/6	$3.61\times {10}^{-4}$	IL2, JAK2	6/15	8/25	8/31
IL-3	0/6	$1$		2/11	2/22	3/43
IL-6	4/8	$7.17\times {10}^{-8}$	AKT1, IL6, JAK1, JAK2	5/13	5/27	5/45
IL-7	1/5	$8.12\times {10}^{-3}$	JAK3	4/12	4/15	4/33
TCR	3/4	$2.32\times {10}^{-5}$	IKBKB, MAP3K7, TNF	4/7	4/9	5/20
TGFB	8/8	$2.01\times {10}^{-14}$	TGFB3, ZFYVE9, AKT1, AXIN1, FKBP1A, GSK3B, MTOR, NEDD4L	9/11	13/37	16/150
TNF-alpha	3/3	$8.82\times {10}^{-6}$	IKBKB, IKBKG, TNF	7/7	11/20	12/40
WNT	3/3	$2.31\times {10}^{-6}$	APC, AXIN1, WNT1	7/9	10/18	14/37