Fig. 1.

Representative data from a single animal demonstrating the calculation for the burden of impaired autoregulation. The four graphs (top to bottom) represent mean arterial pressure (MAP), cerebral blood flow (CBF), cerebral autoregulation index (CBFx) correlating MAP with CBF, and the burden of CBFx >0.3 over the 4 -h post-ROSC monitoring period. The CBFx burden is calculated by the area under the curve (gray shaded areas) representing both the magnitude and duration of impaired cerebral autoregulation. The area under the curve is then normalized as a percentage of the monitoring duration for each animal.