Table 2.
The one-way sensitivity analysis for the five highest impact parameters for in vitro fertilization with preimplantation genetic testing for aneuploidy compared with in vitro fertilization without preimplantation genetic testing for aneuploidy.
| Variable name | Low ICER ($/additional live birth) | High ICER ($/additional live birth) | ICER Spread ($/additional live birth) |
|---|---|---|---|
| Cost of PGT-A ($3,155–$12,626) | 97,488.36 | 28,5702 | 188,213.7 |
| Live birth rate for IVF with PGT-A for a euploid embryo (0.53–0.71) | 80,404.27 | 17,3410.4 | 93,006.17 |
| Confirmed euploid pregnancy in the non PGT-A arm (0.45–0.75) | 96,109.58 | 17,5966.4 | 79,856.82 |
| Probability of having a euploid embryo in the non PGT-A arm (0.45–0.81) | 88,083.3 | 14,8913.9 | 60,830.63 |
| Live birth rate for IVF without PGT-A for a euploid embryo (0.472–0.59) | 94,867.88 | 13,1277 | 36,409.1 |
Note: ICER = incremental cost-effectiveness ratio; IVF = in vitro fertilization; PGT-A = preimplantation genetic testing for aneuploidy.