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. Author manuscript; available in PMC: 2021 Sep 25.
Published in final edited form as: Sci Immunol. 2021 Mar 25;6(57):eabg5413. doi: 10.1126/sciimmunol.abg5413

Figure 4. Regulation of RhCMV vector CD8+ T cell response programming by non-pentameric complex-related genes in the same RhCMV genomic region.

Figure 4.

(A) Schematic representation of the configuration of FL-RhCMV vector in the genetic region of the 68–1 inversion/deletion, compared to modified FL-RhCMV vectors in which the gene segments involved in each end of the 68–1 inversion/deletion (Rh157.5/Rh157.4 and Rh158–162) are separately deleted (single-deleted vectors) or both deleted (e.g., double-deleted or dd vector). (B) Representative MHC restriction analysis of SIVgag-specific CD8+ T cell responses elicited by FL, double-deleted and both single-deleted RhCMV/SIVgag vectors, as described in Fig. 1. Overall epitope analysis results are shown in table S1.