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. Author manuscript; available in PMC: 2021 Sep 25.
Published in final edited form as: Sci Immunol. 2021 Mar 25;6(57):eabg5413. doi: 10.1126/sciimmunol.abg5413

Figure 5. Identification of CMV-encoded inhibitors of unconventionally restricted CD8+ T cell response priming.

Figure 5.

(A,B) Representative MHC restriction analysis of SIV-specific CD8+ T cell responses elicited by double-deleted (dd) FL-RhCMV/SIVgag vectors which were engineered to express Rh157.5 and Rh157.4 alone, Rh157.5 + Rh157.4, or each of the Rh158-Rh161 alone (see fig. S3A–C for genetic configurations), as described in Fig. 1. (C) Representative MHC restriction analysis of SIV-specific CD8+ T cell responses elicited by double-deleted FL-RhCMV/SIVgag vectors which are engineered to individually express UL128, UL130, UL146 and UL147, the HCMV orthologs of the Rh157.5-Rh157.4 and Rh158-Rh161 genes (see fig. S3D for genetic configurations). Note that MHC restriction analysis of the parent dd FL-RhCMV/SIVgag vector-elicited CD8+ T cell response is shown in Fig. 4B (bottom panel). For A-C, overall epitope analysis results are shown in table S1.