Table 3.
Stimulation results and live birth outcomes for INVOCELL cycles at the 5 centers.
| Stimulation Results | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| OHSS | 0% | 1.2% | 1.9% | 1.0% | 0% |
| Mean number of oocytes retrieved | 9.5 | 9.2 | 9.9 | 10.4 | 16 |
| Mean number of oocytes loaded into the INVOCELL device standard Insemination (min–max) | 9.4 (1–30) | 8.4 (2–27) | 8.7 (1–30) | 9.5 (1–34) | 8 (2–21) |
| Mean number of oocytes loaded into the INVOCELL device ICSI (min–max) | N/A | 6.4 (1–25) | N/A | N/A | N/A |
| % Top quality (≥3BB) embryos recovered | 85% | 38% | 77% | 25% | 40% |
| % Blastocysts recovered per oocyte loaded into the INVOCELL device | 19% | 27% | 20% | 34% | 20% |
| Mean number of blastocysts frozen | 0.82 | 1.4 | 1.2 | 2.4 | 3.76 |
| % of cycles that had supernumerary blastocysts to cryopreserve | 32.9% | 23% | 36.5% | 58.7% | 70% |
| Number and percentage of day 5 transfers in which embryos other than blastocysts were transferred | 0; 0% | 9; 8% | 0; 0% | 4; 1.8% | 0; 0% |
| Single embryo transfer | 60% | 71% | 97% | 81% | 87% |
| Implantation rate | 38.8% | 47.0% | 52.9% | 48.2% | 51.4% |
| Multiple pregnancies | 6.8% | 4.2% | 1.9% | 4.3% | 3.2% |
| Live Birth Rates | |||||
| Live birth rate: fresh transfer | |||||
| Per cycle start | 23% (15/64) | 41% (34/83) | 42% (14/33) | 28% (43/153) | 15% (5/34) |
| Per transfer | 35% (15/43) | 50% (34/68) | 64% (14/22) | 54% (43/80) | 45% (5/11) |
| Live birth rate: frozen transfer | |||||
| Per cycle start | 50% (5/10) | 56% (5/9) | 29% (2/7) | 46% (38/83) | 21% (7/34) |
| Per transfer | 50% (5/10) | 56% (5/9) | 29% (2/7) | 46% (38/82) | 37% (7/19) |
| Cumulative Pregnancy Rate (Live Birth and Ongoing Pregnancy) | |||||
| Cumulative pregnancy rate | |||||
| Per cycle start | 29% (21/73) | 32% (52/165) | 46% (30/66) | 33% (101/302) | 53% (18/34) |
| Per transfer | 42% (21/50) | 40% (52/130) | 61% (30/49) | 49% (101/207) | 60% (18/30) |
Note: Single embryo transfer rate is shown as the percentage of total transfers. OHSS rate and multiple pregnancy rate are shown as the percentage of total cycles. Mean number of oocytes retrieved ranged from 9.5 to 16 and mean number of oocyte/sperm complexes loaded in the INVOCELL varied from 8 to 9.5 with a broad range of 1–30 loaded per device for standard insemination and 6.4 with a range of 1–25 for ICSI oocytes. Cycles with fresh transfer or frozen transfer resulting in a live birth (shown as the number of live births per started cycle and per transfer) are indicated for cycles started prior to October 31, 2018. Cumulative pregnancy rate is defined as live birth resulting from fresh and frozen transfers (for cycles started prior to October 31, 2018) plus ongoing pregnancy (for cycles performed between November 1, 2018, and May 31, 2019). For site 5, live birth rate and cumulative pregnancy rate data are shown for the entire time period. ICSI = intracytoplasmic sperm injection; N/A = not available; OHSS = ovarian hyperstimulation syndrome.