Table 2.

Proposed criteria for flagging a potential chromosomal rearrangement.

1) Reciprocal translocations	Predictive value
A terminal, segmental imbalance in ≥2 embryos, involving the same chromosome and the same breakpoint	97% (n = 33)
2) Rob(13;14) translocation
Three or more embryos with complete aneuploidy of chr13 or chr14 with ≥50% of the cohort affected	100% (n = 3)
3) Inversions
Two or more embryos with characteristic inversion “stair” pattern in any cohort size	100% (n = 2)

Note: These criteria are proposed to be applied to the results of a preimplantation genetic testing for aneuploidy cohort to determine the likelihood of a balanced rearrangement in the egg or sperm source. If cases meet the criteria, it is recommended to perform high-resolution karyotyping, followed by FISH analysis in the case of a possible cryptic translocation. The clinical history of the reproductive couple should also be taken into consideration.