Table 1.

Panel of selected integral membrane protein targets studied in this work. Summary of their origin, function, topological features and high-resolution structures (if available). Targets originating from archaeal species are shown in red, from Gram-negative bacteria are shown in black, while from Gram-positive bacteria in blue. UniProt IDs∗ originate from the UniProt database (https://www.uniprot.org/) (UniProt, 2019). ∗∗: The overall topology (given as number of transmembrane (TM) helices), length of N-/C-termini (aa) and their orientation (in: intracellular, out: outside) are based on available crystal structures in the Protein Data Bank (PDB; http://www.rcsb.org/) (Burley et al., 2019) or as indicated in the UniProt database. PDB IDs∗∗∗ originate from the above-mentioned PDB.