Table 1.
Epinephrine #2 Δ | Vasopressin Δ | p | |
---|---|---|---|
Total Cohort (n = 67) | |||
CoPP | 5.43 (1.56–9.82) | 8.16 (4.35–12.06) | 0.02 |
CBF | 0.00 (−0.77 – 18.24) | 14.58 (−0.05–38.12) | 0.01 |
MAP | 5.90 (1.98–13.82) | 8.62 (3.90–13.16) | 0.21 |
Mean PA | 0.04 (−0.80 – 2.98) | 4.05 (0.42–7.80) | <0.001 |
RAP | 0.94 (0.43–1.61) | 0.70 (0.19–1.39) | 0.25 |
ETCO2 | −0.18 (−2.37 – 2.83) | −0.19 (−1.5 – 0.98) | 0.74 |
Epinephrine Responders (n = 47) | |||
CoPP | 6.89 (2.46–10.65) | 8.24 (4.18–13.99) | 0.21 |
CBF | 0.065 (−0.51 – 22.67) | 16.03 (−0.15–44.8) | 0.04 |
MAP | 9.00 (3.32–14.62) | 9.02 (4.40–13.99) | 0.60 |
Mean PA | 0.23 (−0.65 – 2.98) | 4.26 (0.66–8.39) | 0.001 |
RAP | 0.91 (0.43–1.38) | 0.81 (0.91–1.44) | 0.64 |
ETCO2 | −0.02 (−2.11 – 2.93) | −0.18 (−1.31 – 0.98) | 0.63 |
Epinephrine Non-responders (n = 20) | |||
CoPP | 2.76 (1.28–6.58) | 7.64 (4.86–11.02) | 0.22 |
CBF | −0.28 (−2.33 – 6.91) | 14.58 (3.55–34.90) | 0.045 |
MAP | 2.53 (0.91–7.29) | 6.84 (3.68–10.34) | 0.16 |
Mean PA | −0.13 (−1.71 – 2.37) | 2.45 (0.44–6.59) | 0.01 |
RAP | 1.19 (0.49–2.05) | 0.70 (0.22–1.29) | 0.23 |
ETCO2 | −0.82 (−2.86 – 1.29) | −0.47 (−1.87 – 0.90) | 0.95 |
Vasopressor effects were defined as the difference between pre-vasopressor mean and post-vasopressor maximum. Medians are reported with interquartile ranges. These differences were compared using Wilcoxon signed rank statistical tests.
CoPP = coronary perfusion pressure (mmHg); CBF = cerebral blood flow (PFU); MAP = mean arterial pressure (mnHg); Mean PA = mean pulmonary artery pressure (mmHg); RAP = right atrial pressure (mmHg); EtCO2 = end tidal carbon dioxide (mmHg).