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. 2020 Nov 25;4:100050. doi: 10.1016/j.resplu.2020.100050

Table 1.

Comparison of the effects of the second dose of epinephrine in a.) the total cohort (n = 67), b.) epinephrine responders (n = 47), and c.) epinephrine non-responders (n = 20).

Epinephrine #2 Δ Vasopressin Δ p
Total Cohort (n = 67)
CoPP 5.43 (1.56–9.82) 8.16 (4.35–12.06) 0.02
CBF 0.00 (−0.77 – 18.24) 14.58 (−0.05–38.12) 0.01
MAP 5.90 (1.98–13.82) 8.62 (3.90–13.16) 0.21
Mean PA 0.04 (−0.80 – 2.98) 4.05 (0.42–7.80) <0.001
RAP 0.94 (0.43–1.61) 0.70 (0.19–1.39) 0.25
ETCO2 −0.18 (−2.37 – 2.83) −0.19 (−1.5 – 0.98) 0.74
Epinephrine Responders (n = 47)
CoPP 6.89 (2.46–10.65) 8.24 (4.18–13.99) 0.21
CBF 0.065 (−0.51 – 22.67) 16.03 (−0.15–44.8) 0.04
MAP 9.00 (3.32–14.62) 9.02 (4.40–13.99) 0.60
Mean PA 0.23 (−0.65 – 2.98) 4.26 (0.66–8.39) 0.001
RAP 0.91 (0.43–1.38) 0.81 (0.91–1.44) 0.64
ETCO2 −0.02 (−2.11 – 2.93) −0.18 (−1.31 – 0.98) 0.63
Epinephrine Non-responders (n = 20)
CoPP 2.76 (1.28–6.58) 7.64 (4.86–11.02) 0.22
CBF −0.28 (−2.33 – 6.91) 14.58 (3.55–34.90) 0.045
MAP 2.53 (0.91–7.29) 6.84 (3.68–10.34) 0.16
Mean PA −0.13 (−1.71 – 2.37) 2.45 (0.44–6.59) 0.01
RAP 1.19 (0.49–2.05) 0.70 (0.22–1.29) 0.23
ETCO2 −0.82 (−2.86 – 1.29) −0.47 (−1.87 – 0.90) 0.95

Vasopressor effects were defined as the difference between pre-vasopressor mean and post-vasopressor maximum. Medians are reported with interquartile ranges. These differences were compared using Wilcoxon signed rank statistical tests.

CoPP = coronary perfusion pressure (mmHg); CBF = cerebral blood flow (PFU); MAP = mean arterial pressure (mnHg); Mean PA = mean pulmonary artery pressure (mmHg); RAP = right atrial pressure (mmHg); EtCO2 = end tidal carbon dioxide (mmHg).