Fig. 7.

ZnT8 EM map displays a2-fold symmetricdimeric structure that recapitulates the architecture of the bacterial homolog YiiP. Front (A) and side (B) views of the ZnT8 homology model of YiiP fitted into the EM density map calculated at 20 Å resolution. The complex has a height of 90 Å and a girth of 70 Å × 50 Å. Axial sections (C) of density map corresponding to transverse planes in B as indicated. Subunits (orange and yellow), zinc ions (blue spheres), amino-terminal fragment (blue), His₆ tag (green).