Figure 1.

Protective effect of SIRT3 on CLP-induced AKI. (A) Immunohistochemical detection of SIRT3 protein expression in the kidney (IHC, ×200). (B) Quantitative analysis of SIRT3 protein expression. (C) Expression of SIRT3 mRNA in the kidney. (D) Expression levels of Scr in each mice group. (E) Expression levels of pKIM-1 in each mice group. (F) Pathological damage of kidney tissue (H&E, ×200). (G) Pathological score of kidney tissue. SIRT3, Sirtuin3; CLP, cecal ligation, and perforation; AKI, acute kidney injury; Scr, serum creatinine; pKIM-1, plasma kidney injury molecule-1. Compared with WT-Sham group, ^**P<0.01, ^***P<0.001; compared with KO-Sham group, ^***P<0.001; compared with WT-CLP group, ^##P<0.01, ^###P<0.001