Figure 3.

Protective effect of SIRT3 on mitochondrial function in CLP-induced AKI. (A) Effect of SIRT3 deficiency on the mitochondrial structure. (B) Quantitative determination of mean mitochondrial density (μm3) in proximal tubular cells. (C) Expression levels of complex I in the kidney. (D) Expression levels of complex II in the kidney. (E) Expression levels of complex III in the kidney. (F) Expression levels of complex IV in the kidney. SIRT3, Sirtuin3; CLP, cecal ligation and perforation; AKI, acute kidney injury. Compared with WT-Sham group, **P<0.01, ***P<0.001; compared with KO-Sham group,**P<0.01, ***P<0.001; compared with WT-CLP group, #P<0.05, ##P<0.01