Figure 1.

A, Employee-submitted photographs of delayed injection site reactions following the first dose of mRNA-1273. B, A punch biopsy of the skin demonstrated a largely perivascular lymphocytic infiltrate with little epidermal change (left). There is increased spacing of reticular dermal collagen bundles, which suggests associated dermal edema. At higher magnification (right), interstitial neutrophils and eosinophils can be seen. The microscopic findings resemble an urticarial hypersensitivity dermatitis.