Table 1.
Clinical Characteristics and Course of Delayed Injection Site Reaction to mRNA-1273
| Number/Sex/ Age, years | Atopic or Allergic History | Hormone Use | Onset, days | Duration, days | Rash Dimensions, cm | Erythema | Pain | Swelling | Pruritus | Lymphadenopathy | Over-the-Counter Medication Used | Second Vaccine Arm | Reaction to Second Dose | Onset of Second Reaction, days | Duration of Second Reaction, days | Reaction Severity Relative to First Dose |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1/F/41 | N | N | 8 | 2 | 5 × 5 | Y | Y | N | Y | N | N | Opposite | Y | 3 | 2 | Less |
| 2/F/34 | Y | Y | 8 | 3 | 10 × 10 | Y | N | Y | Y | N | N | Opposite | N | N/A | N/A | N/A |
| 3/F/45 | N | N | 5 | 4 | 15 × 8 | Y | N | Y | Y | N | N | Opposite | N | N/A | N/A | N/A |
| 4/F/34 | N | N | 7 | 6 | 15 × 8 | Y | Y | Y | Y | N | N | Opposite | N | N/A | N/A | N/A |
| 5/F/31 | N | N | 7 | 4 | 10 × 8 | Y | N | Y | Y | Y | N | Same | N | N/A | N/A | N/A |
| 6/F/42 | N | N | 7 | 3 | 5 × 5 | Y | N | N | Y | N | N | Same | N | N/A | N/A | N/A |
| 7/F/41 | Y | N | 9 | 3 | 10 × 8 | Y | Y | N | Y | N | Y (diphenhydramine by mouth) | Unknown | N | N/A | N/A | N/A |
| 8/F/41 | N | N | 4 | 7 | 10 × 8 | Y | Y | Y | Y | Y | N | Same | Y | 2 | 5 | Less |
| 9/F/42 | Y | N | 6 | 5 | 13 × 8 | Y | N | Y | Y | N | Y (topical hydrocortisone) | Opposite | Y | 2 | 6 | Less |
| 10/F/39 | Y | Y | 8 | 2 | 15 × 8 | Y | Y | N | Y | N | N | Opposite | N | N/A | N/A | N/A |
| 11/F/35 | Y | Y | 8 | 6 | 10 × 10 | Y | N | Y | Y | N | N | Same | Y | 2 | 3 | Less |
| 12/F/55a | N | N | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | Same | Y | 2 | 3 | N/A |
| 13/F/55 | N | N | 7 | 7 | 10 × 10 | Y | Y | Y | Y | N | N | Opposite | N | N/A | N/A | N/A |
| 14/F/28 | N | N | 3 | 6 | 8 × 5 | Y | Y | Y | Y | N | Y (cetirizine by mouth) | Same | Y | 2 | 7 | Same |
Abbreviation: N/A, not applicable.
aEmployee number 12 only had a reaction to the second vaccine dose.