Table 1:

Some considerations prior to launching a large-scale collaboration.

• Is the research question well-suited to a large-scale collaboration? Is the investment of resources commensurate with the anticipated contribution to knowledge?

• Is there sufficient interest from the research community to support the project? How many labs would be willing/able to contribute data?

• What will the leadership structure be? Is there sufficient conceptual knowledge, technical expertise, and diversity of perspectives?

• What steps will be taken to ensure an inclusive atmosphere and to support mentorship at all levels?

• Is the project feasible? Considerations include ethical approvals, access to relevant populations, methodological expertise, availability of research personnel and equipment, time, and monetary constraints.

• How will the project be administered? What mechanisms will be used to verify methodological standardization and data quality?