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. 2021 Jun 29:M21-1269. doi: 10.7326/M21-1269

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This article is made available via the PMC Open Access Subset for unrestricted re-use for research, analyses, and text and data mining through PubMed Central. Acknowledgement of the original source shall include a notice similar to the following: "© 2020 American College of Physicians. Some rights reserved. This work permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited." These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. Design decisions for ACTIV master protocols. Each decision made for the master protocols was critical for tailoring them to the specific needs of the patients and the portfolio of studies that ACTIV was seeking to create to best address the therapeutic testing needs for the pandemic. ACTIV = Accelerating COVID-19 Therapeutic Interventions and Vaccines. — Each decision made for the master protocols was critical for tailoring them to the specific needs of the patients and the portfolio of studies that ACTIV was seeking to create to best address the therapeutic testing needs for the pandemic. ACTIV = Accelerating COVID-19 Therapeutic Interventions and Vaccines.