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. 2021 Jun 30;23(11):2202–2207. doi: 10.1038/s41436-021-01249-z

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© The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 2 — (a–d) Summary of symptoms and treatment effects. Summary of the symptoms of P^IARS (top left), P^LARS (top right), P^FARSB (bottom left), and P^SARS (bottom right). Colors indicate the generalized treatment effect on the symptom (green: improved; white: stable or stabilized; red: progressed). Standard deviation scores (Z) for height, weight, and head circumference were calculated using Netherlands (NL) reference charts (P^IARS; head circumference of P^LARS), World Health Organization (WHO) reference charts (P^FARSB), Centers for Disease Control and Prevention (CDC) reference charts (height and weight of P^LARS), and French (FR) reference charts (P^SARS). CRP C-reactive protein, FSIQ full-scale intelligence quotient, G-tube gastrostomy-tube, ILD interstitial lung disease, FRI fluid reasoning index, INR international normalized ratio, LI language index, PAP pulmonary alveolar proteinosis, PEG percutaneous endoscopic gastrostomy, PIQ performance intelligence quotient, VIQ verbal intelligence quotient, VCI verbal comprehension index, VSI visual–spatial index, WISC-V Wechsler Intelligence Scale for Children, fifth edition, WPPSI-III/IV Wechsler Preschool and Primary Scale of Intelligence, third/fourth edition. (e–h) Growth charts: Z-scores of height, weight and head circumference for age. Growth charts of height, weight, and head circumference in standard deviation score (Z) of (a) P^IARS (NL reference charts); (b) P^LARS (CDC reference charts for height and weight, NL reference charts for head circumference); (c) P^FARSB (WHO reference charts); and (d) P^SARS (FR reference charts). T in months from start of treatment.