Table 2.
Demographic, and clinical characteristics of EBV-seronegative patients, and comparison by MOG-IgG status.
| Demographic and clinical data | Total N=25 | MOG-IgG positive N=11 | MOG-IgG negative N=14 |
|---|---|---|---|
| Retrospective follow-up time, median (IQR), months | 48 (20–70) | 48 (20–78) | 51 (24–70) |
| Age at first presentation, median (IQR), years | 6.7 (4.4–10.8) | 4.7 (4.2–9.4) | 8.2 (4.4–11.6) |
| Time from disease onset to blood sample collection, median (IQR), years | 0.7 (0.3–1.5) | 1.4 (0.3–2.8) | 0.7 (0.3–1.5) |
| Female, n (%) | 17 (68%) | 9 (82%) | 8 (57%) |
| Race, n (%) | |||
| White | 14 (56%) | 6 (55%) | 8 (57%) |
| Black | 1 (4%) | 0 | 1 (7%) |
| Asian | 4 (16%) | 1 (9%) | 3 (22%) |
| Mixed (White+Asian) | 5 (20%) | 4 (36%) | 1 (7%) |
| Unknown | 1 (4%) | 0 | 1 (7%) |
| Ethnicity, n (%) | |||
| Hispanic | 5 (20%) | 4 (36%) | 1 (7%) |
| Non-Hispanic | 19 (76%) | 7 (64%) | 12 (86%) |
| Unknown | 1 (4%) | 0 | 1 (7%) |
| Positive for DRB1*15:01 or 15:03 | 4 (16%) | 2 (18%) | 2 (14%) |
| Demyelinating phenotype at the onset, n (%) | |||
| Encephalopathy (ADEM-like) | 3 (12%) | 1 (9%) | 2 (14%) |
| ON | 6 (24%) | 4 (36%) | 2 (14%) |
| SC | 4 (16%) | 3 (27%) | 1 (7%) |
| Brainstem, cerebellar or hemispheric | 8 (32%) | 1 (9%) | 7 (50%) |
| Multifocal (ON + SC) | 3 (12%) | 2 (18%) | 1 (7%) |
| Unknown | 1 (4%) | 0 | 1 (7%) |
| History of bilateral ON, n (%) | 10 (40%) | 7 (64%) | 3 (21%) |
| History of recurrent ON, n (%) | 6 (24%) | 5 (45%) | 1 (7%) |
| History of bilateral or recurrent ON, n (%) | 11 (44%) | 7 (64%) | 4 (29%) |
| OCB or increased CSF IgG index, n (%) | |||
| Positive | 2 (8%) | 1 (9%) | 1 (7%) |
| Negative | 16 (64%) | 8 (73%) | 8 (57%) |
| Not tested or not available | 7 (28%) | 2 (18%) | 5 (36%) |
| Second clinical attack during follow-up, n (%) | 18 (72%) | 9 (82%) | 9 (64%) |
| Fulfill McDonald 2017 criteria for MS diagnosis, n (%) | 20 (80%) | 10 (91%) | 10 (71%) |
| MS disease-modifying treatments, n (%) | |||
| Received | 18 (72%) | 8 (73%) | 10 (71%) |
| Did not receive | 6 (24) | 2 (18%) | 4 (29%) |
| Unknown | 1 (4%) | 1 (9%) | 0 |
MOG: myelin oligodendrocyte glycoprotein, ADEM: acute disseminated encephalomyelitis, ON: optic neuritis, SC: spinal cord