Figure2.

The co-expression of TIGIT and TIM-3 is elevated on NK cells of progression patients with HBV-HCC. a-b Percentages of TIGIT⁺TIM-3⁺NK cells on total NK cells and NK cell subsets(CD56^brightNK cells,CD56^dimNK cells, and CD56⁻NK cells) from HBV-HCC, HDs, CHB and HBV-LC patients by flow cytometry analysis. c Correlation analysis of TIGIT and TIM-3 on NK cells from patients with HBV-HCC. d-e Flow-cytometry analyses (d) of TIGIT and TIM-3 were performed on PBMCs collected from HBV-HCC patients. Representative plots (e) display the expression of TIGIT⁺NK cells, TIM-3⁺NK cells and total TIGIT⁺TIM-3⁺NK cells from patients with progression (n = 61) and no progression (n = 72). P values were calculated by using the Kruskal–Wallis nonparametric H test (a-c). P values were obtained by the unpaired t test (d-e). * P < .05, **P < .01, ***P < .001, ****P < .0001