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. 2021 Jun 28;10(1):1942673. doi: 10.1080/2162402X.2021.1942673

Figure5.

Figure5.

TIGIT+TIM-3+NK cells in HBV-HCC patients are functionally exhausted. a-c Intracellular staining for IFN-γ (a), TNF-α (b) and CD107a (c) in TIGIT+TIM-3+NK cells from HBV-HCC patients (n = 30) upon in vitro stimulation for IL-12, IL-15, and IL-18 (100, 20, and 100 ng/ml, respectively).d Percentage of expression of Ki67 (d) on TIGIT−TIM-3−, TIGIT+TIM-3−, TIGIT−TIM-3+ and TIGIT+TIM-3+ NK cells from patients with HBV-HCC (n = 8).e Representative flow cytometry data and histogram showing the percentage of T-betloEomeshi and T-bethiEomeslo cells (e) in different subpopulations of TIGIT+TIM-3+ NK cells from patients with HBV-HCC (n = 8). P values were obtained by the Kruskal–Wallis ANOVA test. *P < .05, **P < .01, ***P < .001