Figure 5.

Sustained in vivo immune response performed by the DMSNs. ELISA-determined anti-B₂T peptide responses obtained in vaccination trial II ( Table SI-2 ) of mice vaccinated with B₂T@Montanide™ (red circle, n=3), B₂T@DMSNs-57nm (purple up triangle, n=5) and B₂T@DMSNs-156nm (green down triangle, n=5) from sera collected on the indicated days post-immunization (20, 40, 60, and 80 pi). Each point depicts mean antibody titers (calculated as described in Materials and methods) ± SD for each group. No individual spontaneous reactivity was observed in the titers determined at day 0. (cf. §SI-3; Table SI-2, and Figures SI-14, SI-15, and SI-16 ).