Table IV.
Univariable association of blood marker results categorized by clinically relevant cutoffs and acute readmission.
| Preoperative blood marker | TKA | THA | ||||||
|---|---|---|---|---|---|---|---|---|
| Development (2011 to 2016) | Validation (2017 to 2018) | Development (2011 to 2016) | Validation (2017 to 2018) | |||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Albumin, g/l | ||||||||
| Low (0 to 34) | 1.88 (1.60 to 2.20) | < 0.0001 | 2.43 (2.05 to 2.89) | < 0.0001 | 2.01 (1.63 to 2.48) | < 0.0001 | 2.59 (2.26 to 2.96) | < 0.0001 |
| Normal (35+) | Ref. | Ref. | Ref. | Ref. | ||||
| Haematocrit, l/l | ||||||||
| Low (M: < 45, F: < 37) | 1.48 (1.37 to 1.61) | < 0.0001 | 1.57 (1.42 to 1.73) | < 0.0001 | 1.18 (1.07 to 1.31) | 0.0011 | 1.45 (1.28 to 1.60) | < 0.0001 |
| Normal | Ref. | Ref. | Ref. | Ref. | ||||
| Platelets, 109/l | ||||||||
| Low (0 to 139) | 1.59 (1.33 to 1.91) | < 0.0001 | 1.83 (1.47 to 2.28) | < 0.0001 | 1.73 (1.35 to 2.20) | < 0.0001 | 1.65 (1.23 to 2.22) | 0.0007 |
| Normal (140+) | Ref. | Ref. | Ref. | Ref. | ||||
| WBC, 109/l | ||||||||
| Low/Normal (0 to 11) | Ref. | Ref. | Ref. | Ref. | ||||
| High (12+) | 1.37 (1.14 to 1.65) | < 0.0001 | 1.45 (1.16 to 1.82) | 0.0012 | 1.67 (1.35 to 2.07) | < 0.0001 | 1.67 (1.30 to 2.16) | < 0.0001 |
| eGFR, ml/min/1.73m2 | ||||||||
| Severe (< 30) | 3.32 (2.50 to 4.42) | < 0.0001 | 3.99 (2.78 to 5.72) | < 0.0001 | 2.30 (1.50 to 3.51) | < 0.0001 | 3.99 (2.60 to 6.13) | < 0.0001 |
| Mild/Mod. (30 to 89) | 1.25 (1.15 to 1.37) | 1.34 (1.21 to 1.50) | 1.09 (0.98 to 1.21) | 1.34 (0.17 to 1.53) | ||||
| Normal (≥ 90) | Ref. | Ref. | Ref. | Ref. | ||||
| Sodium, mmol/l | ||||||||
| Low (< 135) | 1.56 (1.32 to 1.85) | < 0.0001 | 1.39 (1.10 to 1.76) | 0.0199 | 1.35 (1.08 to 1.68) | < 0.0001 | 1.67 (1.26 to 2.15) | 0.0004 |
| Normal (135 to 147) | Ref. | Ref. | Ref. | Ref. | ||||
| High (≥ 148) | 1.14 (0.51 to 2.59) | 0.61 (0.15 to 2.48) | 3.94 (1.96 to 7.92) | 0.93 (0.23 to 3.81) | ||||
Odds ratios (OR) are unadjusted. Variables are considered statistically significant if p < 0.0005 is maintained across both development and validation cohorts.
CI, confidence interval; eGFR, estimated glomerular filtration rate; Mod, moderate; N/A, not applicable; Ref, reference category; THA, total hip arthroplasty; TKA, total knee arthroplasty; WBC, white blood cell count.