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. Author manuscript; available in PMC: 2021 Jun 30.
Published in final edited form as: J Med Chem. 2021 Jun 10;64(12):8739–8754. doi: 10.1021/acs.jmedchem.1c00748

Table 2.

In Vivo Blood-Stage Antimalarial Oral Efficacy of PGs and TAs

compound in vivo %parasitemia reduction on day 5 at ED50 mg/kg/d ED90 mg/kg/d
5 mg/kg/4d 25 mg/kg/4d
PEG-400 0 0 - -
2 0 0 - -
3 0 6 - -
4 0 9 - -
5 25 37 - -
6a 65 100 2.7 5.9
(E/Z)-7 0 100 15 16
21 60 100 3.6 18
24a 63 100 3.7 17
25a 67 100 2.5 8.5
26a 70 100 1.5 4.8
27a 89 100 2.6 9.2
39 0 42 - -
CQ 100 100 1.5 3.3
a

Curative at 25 mg/kg/day