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. 2021 Jun 18;15(6):e0009430. doi: 10.1371/journal.pntd.0009430

Table 1. Socio-demographic and clinical characteristics of Patients with Nodding Syndrome, Central African Republic, 2019.

Characteristics 1 2 3 4 5
Age (years) 11 8 16 8 15
Sex Female Female Female Female Female
Place of Birth Ouango Mbaïki Ouango Ouango Gboko
Age at HNa onset (year) 8 (2014) 5 (2016) 8 (2011) 8 (2019) 12 (2016)
Other epilepsy Generalized tonic-clonic No epilepsy Generalized myoclonic No epilepsy No epilepsy
Winkler’s classification HN plus HN only HN plus HN only HN only
WHOb‘s classification Confirmed Probable Probable Probable Probable
Frequency (HN/min) 8 6–10 NA 11–15 5
Trigger factor Noise Cold Noise, heat None Meal, cold
Neurological examination Abnormal/focal Abnormal Abnormal/focal Abnormal Abnormal/focal
Developmental delay and cognitive decline Moderate Mild No Moderate No
Growth retardation Yes No No Yes No

aHN, head nodding.

bWHO, World Health Organization.