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. 2021 Jun 16;12:668369. doi: 10.3389/fimmu.2021.668369

Figure 7.

Figure 7

Molecules implicated in the mechanism of IL-4 regulation mediated by NLRP3 are associated with CTCL progression. (A) Clinical photographs of the lesions from representative slow (left) and fast (right) progressor CTCL patients. Hematoxylin-eosin (HE) staining in a slow and fast progressor CTCL patient. Representative immunofluorescence images of the expression of TOX (AF-594) and IL-4 (AF-647) (mid panel) and TOX (AF-594) and NLRP3 (AF-647) (bottom panel) in biopsies from representative slow progressor and fast progressor CTCL patients. Quantification of the total expression of (B) TOX, IL-4 and NLRP3 in the microphotographs of the representative slow progressor and fast progressor patient of CTCL from (A). Black arrows indicate Pautrier microabscesses, and white arrows indicate coexpression of markers in the different staining. Error bars = SEM. *P < 0.05; **P < 0.01. Scale bar, 20 nm.